[Calcium antagonists and insulin resistance]
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Updated: Aug 15, 2026

Homogeneous Time-resolved Förster Resonance Energy Transfer-based Assay for Detection of Insulin Secretion
Published on: May 10, 2018
Yukihito Higashi1, Masao Yoshizumi
1Department of Cardiovascular Physiology and Medicine, Graduate School of Biomedical Sciences, Hirosima University.
Insights
Calcium antagonists treat hypertension and ischemic heart disease, reducing cardiovascular events. This review examines their impact on insulin resistance, a key factor in cardiovascular outcomes.
Area of Science:
- Cardiology
- Endocrinology
- Pharmacology
Context:
- Calcium antagonists are established treatments for hypertension and ischemic heart disease.
- Insulin resistance is an independent predictor of cardiovascular outcomes.
- Cardiovascular diseases share associations with insulin resistance, contributing to atherosclerosis.
Purpose:
- To review the effects of calcium antagonists on insulin resistance (insulin sensitivity).
Summary:
- Calcium antagonists are effective in preventing cardiovascular mortality and morbidity.
- Insulin resistance is a crucial factor in the development of atherosclerosis and cardiovascular disease.
- Selecting interventions that improve insulin resistance is clinically important for managing cardiovascular diseases.
Impact:
- Provides insights into the role of calcium antagonists in metabolic health.
- Highlights the clinical significance of managing insulin resistance in cardiovascular patients.
- Informs therapeutic strategies for patients with hypertension, ischemic heart disease, and insulin resistance.
Abstract:
Calcium antagonists have become available for the treatment of hypertension and ischemic heart diseases. Large clinical trials have demonstrated that calcium antagonists prevent cardiovascular mortality and morbidity. Epidemiologic studies have shown insulin resistance is an independent predict factor for cardiovascular outcome. Cardiovascular diseases, including hypertension, diabetes mellitus, and hyperlipidemia are associated with insulin resistance. Insulin resistance is an initial step in atherosclerosis, leading to increase in the incidences of cardiovascular outcome. From a clinical perspective, it is important to select an appropriate intervention which is effective in improving insulin resistance in cardiovascular diseases. In this review, we would like to focus on the effects of calcium antagonists on insulin resistance (insulin sensitivity).
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