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Familial papillary thyroid carcinoma
Carl D Malchoff1, Diana M Malchoff
1University of Connecticut Health Center, 263 Farmington Avenue Farmington, CT 06030, USA.
Cancer Treatment and Research
|October 8, 2005
Summary
Genetic susceptibility to familial papillary thyroid carcinoma (fPTC) is supported by accumulating evidence. Research is identifying fPTC genes and clinical characteristics, leading to a structured diagnostic approach.
Area of Science:
- Genetics and Molecular Biology
- Endocrinology
- Oncology
Background:
- Familial papillary thyroid carcinoma (fPTC) is a distinct clinical entity.
- Evidence suggests a genetic basis for fPTC, necessitating the identification of susceptibility genes.
Purpose of the Study:
- To review the current evidence supporting the existence of fPTC susceptibility genes.
- To outline preliminary clinical characteristics of fPTC.
- To discuss the identification of chromosomal locations for putative fPTC genes.
Main Methods:
- Review of accumulated evidence over the last decade.
- Analysis of preliminary clinical data.
- Summary of findings from linkage studies identifying chromosomal locations.
Main Results:
- Multiple lines of evidence support the existence of fPTC susceptibility genes.
- Preliminary clinical features of fPTC have been defined.
- Linkage studies have pinpointed chromosomal regions harboring potential fPTC genes.
Conclusions:
- The genetic underpinnings of fPTC are increasingly recognized.
- A structured clinical approach to managing fPTC is becoming feasible based on emerging genetic and clinical data.