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Updated: Jan 1, 2026

Synthesis and Bioconjugation of Thiol-Reactive Reagents for the Creation of Site-Selectively Modified Immunoconjugates
Published on: March 6, 2019
New conjunctive reagents as cross-coupling partners en route to retinoid-like polyenes
Bruce H Lipshutz1, Giuliano C Clososki, Will Chrisman
1Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106, USA. lipshutz@chem.ucsb.edu
Abstract:
[structure: see text] New conjunctive reagents E-2 and Z-3 can be used, after transmetalation, in Negishi couplings with vinyl and aryl iodides. The subsequently unmasked terminal alkynes can be further manipulated to arrive at retinoid-like products.
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