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Solid-phase Synthesis of [4.4] Spirocyclic Oximes
Published on: February 6, 2019
Unusual Tandem alkynylation and trans-hydrosilylation to form oxasilacyclopentenes
1Department of Chemistry, University of Wisconsin, Madison, 53706, USA.
Abstract:
[reaction: see text] An unusual tandem reaction sequence to form oxasilacyclopentenes from carbonyls and alkynylsilanes in the presence of a catalytic amount of nucleophilic initiator has been discovered. The reaction proceeds readily at room temperature and is applicable to a wide variety of carbonyl substrates. While the reaction scope tolerates variable substitutions on the alkynylsilane, phenylacetylene-derived silane variants consistently achieved the best yield.
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