Related Experiment Video
Updated: Aug 14, 2026
10:00
Supramaximal Intensity Hypoxic Exercise and Vascular Function Assessment in Mice
Published on: March 15, 2019
Bemithyl potentiates the antioxidant effect of intermittent hypoxic training
I V Zarubina1, F N Nurmanbetova, P D Shabanov
1Department of Pharmacology, Russian Military Medical Academy, St. Petersburg.
Bulletin of Experimental Biology and Medicine
|November 12, 2005
Summary
Bemithyl treatment enhanced rats' metabolic adaptation to hypoxic hypoxia. This drug increased resistance to low oxygen levels, offering a lasting protective effect.
Area of Science:
- Physiology
- Pharmacology
- Biochemistry
Background:
- Hypoxic hypoxia poses physiological challenges.
- Adaptive responses are crucial for survival under low oxygen conditions.
- Pharmacological interventions may enhance hypoxia tolerance.
Purpose of the Study:
- To investigate the effects of Bemithyl on adaptive metabolic changes in rats exposed to hypoxic hypoxia.
- To determine if Bemithyl enhances individual resistance to hypoxia.
- To assess the duration of Bemithyl's effects.
Main Methods:
- Rats were subjected to intermittent training in a flow pressure chamber for 3 days to induce hypoxic hypoxia.
- Bemithyl (25 mg/kg, intraperitoneally) was administered daily starting after the first day of training.
- Metabolic changes and resistance to hypoxia were evaluated.
Main Results:
- Bemithyl treatment potentiated adaptive metabolic changes in the rat brain.
- The drug significantly increased individual resistance to hypoxic hypoxia.
- The observed effects of Bemithyl were long-lasting.
Conclusions:
- Bemithyl is effective in enhancing metabolic adaptation to hypoxic hypoxia.
- Bemithyl treatment improves physiological resilience to low oxygen environments.
- The findings suggest Bemithyl has potential as a hypoxia-protective agent.
