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Plasma cell balanitis treated with tacrolimus 0.1%.
G A Moreno-Arias1, A Camps-Fresneda, C Llaberia
1Centro Médico Teknon, Despacho 27, Vilana 12, 08190 Barcelona, Spain. 935893067@telefonica.net
The British Journal of Dermatology
|November 26, 2005
Summary
Topical tacrolimus 0.1% ointment effectively treats balanitis of Zoon (BZ) in men. This study shows marked improvement in patients resistant to other treatments, indicating a safe therapeutic option.
Area of Science:
- Dermatology
- Urology
Background:
- Plasma cell balanitis, also known as Zoon's balanitis (BZ), is a common condition in mature men.
- Lesions typically affect the glans penis and may extend to the prepuce.
- The exact cause of Zoon's balanitis remains unknown.
Observation:
- This study evaluated tacrolimus 0.1% ointment for treating two male patients with BZ.
- Both patients had lesions refractive to conventional topical treatments.
- Tacrolimus 0.1% ointment was applied twice daily.
Findings:
- Both patients experienced significant improvement in BZ lesions.
- Follow-up periods were 1 year and 10 months, respectively.
- Tacrolimus demonstrated efficacy in managing refractory BZ.
Implications:
- Topical tacrolimus 0.1% ointment is a safe and effective treatment for Zoon's balanitis.
- This offers a new therapeutic avenue for patients unresponsive to other treatments.
- Further research may explore long-term outcomes and optimal application protocols.