Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Autoimmune hepatitis.

Joseph Ahn1, Steven L Flamm

  • 1Division of Hepatology, Northwestern University, Feinberg School of Medicine, 675 N. St. Clair , Suite # 15-250, Chicago, IL 60611, USA.

Current Treatment Options in Gastroenterology
|November 30, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

AGA Clinical Practice Update on Management of Hepatitis Delta: Commentary.

Gastroenterology·2025
Same author

Targeting Hsp70 Immunosuppressive Signaling Axis with Lipid Nanovesicles: A Novel Approach to Treat Pancreatic Cancer.

Cancers·2025
Same author

Scaffold implantation <i>vs.</i> intravenous delivery: a comparative preclinical animal study evaluating peroxisome proliferator-activated receptor gamma coactivator 1-alpha adipose-derived stem cells in liver fibrosis treatment.

Annals of surgical treatment and research·2025
Same author

AGA Clinical Practice Update on Management of Portal Vein Thrombosis in Patients With Cirrhosis: Expert Review.

Gastroenterology·2024
Same author

AGA Clinical Practice Update on Pregnancy-Related Gastrointestinal and Liver Disease: Expert Review.

Gastroenterology·2024
Same author

Key Insights and Clinical Pearls in the Identification and Management of Cirrhosis and Its Complications.

The American journal of medicine·2024
Same journal

Esophageal Disorders in the Older Adult.

Current treatment options in gastroenterology·2025
Same journal

Endobariatrics: a Still Underutilized Weight Loss Tool.

Current treatment options in gastroenterology·2023
Same journal

Management of Post Ablative Barrett's Esophagus: a Review of Current Practices and Look at Emerging Technologies.

Current treatment options in gastroenterology·2023
Same journal

Inflammatory Bowel Disease Therapy and Venous Thromboembolism.

Current treatment options in gastroenterology·2023
Same journal

Ileal Pouch-Anal Anastomosis in the Older Adult: a Review of Postoperative Outcomes and Pouchitis Treatment.

Current treatment options in gastroenterology·2023
Same journal

Celiac Disease in the Elderly.

Current treatment options in gastroenterology·2023
See all related articles

Autoimmune hepatitis (AIH) is an inflammatory liver disease treated with immunosuppressants like prednisone and azathioprine (AZA). Research is ongoing for new therapies to improve outcomes and reduce side effects in refractory cases.

Area of Science:

  • Hepatology
  • Immunology
  • Internal Medicine

Background:

  • Autoimmune hepatitis (AIH) is a progressive, inflammatory liver disease of unknown cause.
  • Diagnosis relies on International Autoimmune Hepatitis Group criteria and scoring systems.
  • Standard treatment involves immunosuppression, typically prednisone with or without azathioprine (AZA).

Purpose of the Study:

  • To review current diagnostic criteria and therapeutic strategies for autoimmune hepatitis.
  • To discuss treatment goals, outcomes, and management of treatment failure or toxicity.
  • To explore emerging therapies and the need for further clinical trials.

Main Methods:

  • Review of established diagnostic criteria and scoring systems for AIH.
  • Analysis of standard immunosuppressive therapies (prednisone, AZA) and their combination.

Related Experiment Videos

  • Evaluation of treatment outcomes, including remission, relapse, and failure.
  • Exploration of management strategies for medication toxicity and advanced disease (cirrhosis).
  • Assessment of novel therapeutic agents and future research directions.

    • Main Results:

    • Combination therapy with prednisone and AZA allows lower individual doses, reducing side effects.
    • Treatment aims for complete biochemical, clinical, and histologic remission.
    • Liver transplantation is an option for decompensated cirrhosis.
    • Newer agents like cyclosporine show promise but require larger trials.

    Conclusions:

    • Effective management of AIH involves tailored immunosuppression and supportive care.
    • Further research is essential to develop novel therapeutics with improved safety and efficacy profiles.
    • Addressing treatment refractory cases and medication toxicity remains a clinical challenge.