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Alpha-adrenergic blockers on ventricular automatism in rat heart
Revista Espanola De Fisiologia
|March 1, 1977
Summary
Alpha-adrenergic receptors do not appear to cause cardiac arrhythmias in isolated rat right ventricles. Alpha-blocking drugs were ineffective in preventing arrhythmias, suggesting other mechanisms are involved.
Area of Science:
- Cardiovascular Physiology
- Pharmacology
Background:
- Cardiac arrhythmias can arise from various physiological mechanisms.
- The role of alpha-adrenergic receptors in ventricular automatism and arrhythmia genesis is not fully understood.
Purpose of the Study:
- To investigate the involvement of alpha-adrenergic receptors in experimentally induced cardiac arrhythmias in the isolated rat right ventricle.
Main Methods:
- Isolated rat right ventricle preparations were used.
- Cardiac automatism was induced experimentally.
- Six different alpha-adrenergic blocking agents were administered: phenoxybenzamine, dibenamine, phentolamine, tolazoline, azapetine, and SY-28.
Main Results:
- Administration of the tested alpha-adrenergic blocking agents did not alter the induced automatism.
- These drugs were ineffective in abolishing the arrhythmias.
Conclusions:
- The study suggests that alpha-adrenergic receptors, if present in the rat ventricle, do not play a significant role in the genesis of these specific arrhythmias.
- Alpha-blocking drugs are ineffective in abolishing arrhythmias induced by increased Purkinje fiber activity in this model.