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Facile Preparation of 4-Substituted Quinazoline Derivatives
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Microwave-assisted concise total syntheses of quinazolinobenzodiazepine alkaloids

Ji-Feng Liu1, Mira Kaselj, Yuko Isome

  • 1ArQule, Inc., Division of Chemical Technologies, 19 Presidential Way, Woburn, Massachusetts 01801, USA. jliu@arqule.com

The Journal of Organic Chemistry
|December 6, 2005
PubMed

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Azide ions act as good nucleophiles and react with unhindered alkyl halides to form alkyl azides. Alkyl azides do not participate in further nucleophilic substitution reactions, thereby eliminating the chances of polyalkylated products. Alkyl azides are reduced by hydride-based reducing agents, like lithium aluminum...
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