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Transient Middle Cerebral Artery Occlusion Model of Neonatal Stroke in P10 Rats
Published on: April 21, 2017
Perinatal arterial stroke: understanding mechanisms and outcomes
Yvonne W Wu1, John K Lynch, Karin B Nelson
1Department of Neurology, University of California San Francisco, San Francisco, California 94117, USA.
Seminars in Neurology
|December 13, 2005
Summary
Perinatal arterial stroke, a significant cause of childhood neurological issues, affects neonates at a rate comparable to adult large-vessel ischemic stroke. Understanding its causes and outcomes is crucial for early intervention and improved prognoses.
Area of Science:
- Neurology
- Pediatrics
- Obstetrics
Background:
- Arterial ischemic stroke in neonates is a growing concern for childhood neurological disability.
- Neonatal stroke incidence mirrors adult large-vessel ischemic stroke rates.
- Perinatal stroke risk is linked to prenatal, intrapartum, and postnatal complications.
Purpose of the Study:
- To review the incidence, clinical presentation, pathogenesis, risk factors, and outcomes of perinatal arterial ischemic stroke.
- To highlight the association between maternal and neonatal conditions and perinatal stroke.
- To discuss the variable outcomes and potential for non-hemiparetic presentation in affected infants.
Main Methods:
- Literature review of perinatal arterial ischemic stroke.
- Analysis of associated maternal conditions (e.g., prothrombotic disorders, placental complications).
- Examination of neonatal risk factors (e.g., congenital heart disease, infections).
Main Results:
- Maternal factors like prothrombotic disorders and placental issues contribute to fetal stroke risk.
- Neonatal factors including congenital heart disease and infections predispose infants to stroke.
- Perinatal stroke can manifest as seizures or be detected later through developmental changes like pathological handedness.
Conclusions:
- Perinatal arterial ischemic stroke is an increasingly recognized condition with diverse causes and presentations.
- While hemiparesis is common, up to 50% of affected newborns may not develop this specific deficit.
- Further research is needed to fully characterize the factors influencing perinatal stroke outcomes.
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