Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Immunology of the bladder.

S D Graham1

  • 1Department of Surgery, Emory University School of Medicine, Atlanta, Georgia.

The Urologic Clinics of North America
|August 11, 1992
PubMed
Summary

Immunologic changes in bladder transitional epithelium during malignancy, such as antigen deletions and altered adhesion molecules, offer potential prognostic markers for early cancer detection and patient outcomes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Supersolidity in Two-Dimensional Trapped Dipolar Droplet Arrays.

Physical review letters·2021
Same author

Roton Excitations in an Oblate Dipolar Quantum Gas.

Physical review letters·2021
Same author

Longitudinal Spin Diffusion in a Nondegenerate Trapped ^{87}Rb Gas.

Physical review letters·2015
Same author

Outbreak of epizootic haemorrhagic disease on the island of Réunion.

The Veterinary record·2004
Same author

Ureteral rhabdomyosarcoma.

Urology·2001
Same author

African horse sickness epidemiology: vector competence of south african Culicoides species for virus serotypes 3, 5 and 8.

Medical and veterinary entomology·2000

Area of Science:

  • Oncology
  • Immunology
  • Biochemistry

Background:

  • Immunobiology techniques are transitioning from research to clinical applications.
  • Malignant transformation of bladder transitional epithelium involves distinct immunologic alterations.

Purpose of the Study:

  • To identify and evaluate immunologic changes in bladder cancer with potential prognostic value.
  • To explore novel biomarkers for transitional-cell carcinoma detection.

Main Methods:

  • Analysis of immunologic markers including ABO(H) blood group antigens, Lewis antigens, beta-2 microglobulin, and MHC class 1 heavy chain.
  • Assessment of cellular adhesion molecules, integrins, ras oncogene products, Thomsen-Friedenreich antigen, and epidermal growth factor receptor.
  • Investigation of antigens potentially unique to transitional-cell carcinoma.

Main Results:

  • Observed changes include deletion of ABO(H) antigens and aberrant expression of Lewis antigens.
  • Loss of beta-2 microglobulin and MHC class 1 heavy chain are noted.
  • Alterations in cellular adhesion molecules, integrins, and expression of oncogene products and growth factor receptors are identified.

Conclusions:

  • Immunologic changes in bladder transitional epithelium during malignancy are recognizable and may serve as prognostic indicators.
  • Specific antigen alterations and molecular markers show promise for improving transitional-cell carcinoma diagnosis and prognosis.

Related Experiment Videos