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Mouse Models Of Helicobacter Infection And Gastric Pathologies
Published on: October 18, 2018
Relation between gallbladder neoplasm and Helicobacter hepaticus infection
1Department of Pathology, Kathmandu Medical College, Sinamangal, Kathmandu. saibinita@yahoo.com
Kathmandu University Medical Journal (KUMJ)
|January 3, 2006
Summary
Helicobacter hepaticus infection is prevalent in 82% of gallbladders, with a high association in gallbladder cancer cases. This suggests H. hepaticus may be a significant risk factor for gallbladder disease and malignancy.
Area of Science:
- Gastroenterology
- Pathology
- Oncology
Background:
- Gallstones (cholelithiasis) are a common condition.
- Histopathological changes in the gallbladder are diverse.
- The role of infections in gallbladder disease pathogenesis requires further investigation.
Purpose of the Study:
- To investigate histopathological changes in gallbladders with cholelithiasis.
- To determine the correlation between these changes and Helicobacter hepaticus infection.
Main Methods:
- Analysis of 380 cholecystectomy specimens.
- Histopathological examination using Hematoxylin & Eosin staining.
- Detection of Helicobacter hepaticus using Warthin Starry Silver stain.
Main Results:
- Chronic cholecystitis was the most common finding (43% in the study group).
- Helicobacter hepaticus infection was present in 82% of the study group.
- A high prevalence of H. hepaticus was observed in malignant cases (87.5%).
Conclusions:
- Gallbladder neoplasm is relatively common in Nepal (2.63%).
- Helicobacter hepaticus infection is highly prevalent in gallbladders with cholelithiasis and associated pathologies.
- Further research is needed to establish H. hepaticus as a causative agent or risk factor in gallbladder carcinoma development.
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