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Study of Helicobacter hepaticus in gallbladders with cholelithiasis and its sensitivity pattern
1Department of Pathology, Kathmandu Medical College & Teaching Hospital, Sinamangal, Nepal. saibinita@yahoo.com
Kathmandu University Medical Journal (KUMJ)
|January 15, 2010
Summary
Helicobacter hepaticus infection is common in gallstones, affecting over 76% of patients. Treating this bacterial infection with sensitive antibiotics may help prevent gallstone formation and reduce healthcare costs.
Area of Science:
- Gastroenterology
- Microbiology
- Pathology
Background:
- Cholelithiasis (gallstones) is a prevalent surgical condition with an unclear etiology.
- Bacterial presence in bile and gallstones is significant, but the causal relationship remains debated.
- The natural history of gallstone formation and the role of bacterial infection require further elucidation.
Purpose of the Study:
- To investigate the association between Helicobacter hepaticus infection and cholelithiasis.
- To determine the antibiotic sensitivity patterns of Helicobacter hepaticus in patients with gallstones.
Main Methods:
- Prospective analysis of 30 cholecystectomy specimens from gallstone patients.
- Bacterial culture on Blood agar and Chocolate agar for microaerophilic conditions.
- Identification of Helicobacter hepaticus using Gram stain, biochemical tests, and Warthin-Starry silver stain.
Main Results:
- Helicobacter hepaticus growth positivity observed in 76.66% of cases.
- Nitrofurantoin demonstrated the highest sensitivity (95.7%) against Helicobacter hepaticus.
- Amoxycillin showed the lowest sensitivity (57%) for Helicobacter hepaticus.
Conclusions:
- Helicobacter hepaticus infection is frequently associated with cholelithiasis (76.66%).
- Targeted antibiotic therapy with sensitive agents can potentially control infection and reduce gallstone incidence.
- Managing Helicobacter hepaticus infection may lower healthcare expenditure associated with gallbladder disease.
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