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Using Fluorescence Activated Cell Sorting to Examine Cell-Type-Specific Gene Expression in Rat Brain Tissue
Published on: May 28, 2015
[Expression of GABA(A) receptor alpha1 subunit mRNA in rat flocculus after unilateral labyrinthectomy]
1Department of Otorhinolaryngology, Union Hospital, Huazhong University of Science and Technology, Wuhan, 430022, China.
Objective:
To elucidate the role of the GABA(A) receptor alpha1 subunit in rat flocculus in the recovery from unilateral labyrinthectomy.
Method:
We used a real-time quantitative reverse transcription polymerase chain reaction method to investigate the mRNA expression of the GABA(A) receptor a1 subunit in the flocculus of the rat 1 and 7 day following the lesion.
Result:
GABA(A) receptor a1 subunit was expressed in the flocculus, but no difference in the expression of GABA(A) receptor a1 subunit mRNA could be detected between the ipsilateral and contralateral flocculus at any time following the lesion.
Conclusion:
Our study shows that there is GABA(A) receptor a1 subunit in the rat flocculus. Our data suggest that the expression change of GABA(A) receptor alpha1 subunit mRNA in the flocculus most probably is not involved in the early stage of the vestibular compensation process.
