[Alternative causes of obesity]
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Updated: Aug 13, 2026

A Chronic High-Intensity Interval Training and Diet-Induced Obesity Model to Maximize Exercise Effort and Induce Physiologic Changes in Rats
Published on: April 28, 2023
Arne V Astrup1, Stephan Rössner, Thorkild I A Sørensen
1Den Kongelige Veterinaer og Landbohøjskole, Levnedsmiddelcentret, Institut for Human Ernaering, Huddninge Universitetssjukhus, Overviktsenheten, og Center for Sundhed og Samfund.
Abstract:
The prevailing understanding of the causes of obesity is based on the disturbance of the thermodynamic law of energy balance, primarily through increased intake or decreased expenditure of energy. Alternative causes of obesity, which still respect the law but also allow for primary fat accumulation, are: virus infection of fat cells, energy supply from bacterial fermentation of indigestible food components, psychosocial factors mediated by psychoneuroendocrine pathways, sleeplessness or poor quality of sleep and early life programming, in addition to the well-known and proven genetic programming.
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