Related Experiment Video
Updated: Aug 13, 2026

Establishment and Evaluation of a Sheep Model of Full-thickness Osteochondral Defect
Published on: April 14, 2026
[Features of regeneration of joint cartilage during osteoarthritis]
Abstract:
In order to define the features of regeneration of joint cartilage during osteoarthritis, morphological study of surgical material, obtained from 50 patients, has been performed with the help of histological, histochemical and morphometric methods. In the joint cartilage, alongside with the alteration, there is also the cellular regeneration expressing in the intensive proliferation of cartilaginous cells. However, maturing of the regenerated cells proceeds defectively and consequently regenerate loses ability to be differentiated in hyaline, joint cartilage that specifies the phase of differentiation. Hence, the specified process should be qualified as not reparation, but as a pathological regeneration. Cartilaginous regenerate is not capable to carry out amortization and protective functions of an articulate cartilage and is exposed to secondary alteration. The last, in turn, aggravates arthroses changes and causes progressing disease.
Related Concept Videos
Growth of Cartilage and Bone Tissue
Development of the Limb Synovial Joints
The mesenchymal stem cells differentiate into chondrocytes that form the hyaline cartilage, and later the cartilaginous model of the bone. This model further transforms into a bone. This process is known as endochondral ossification.
During development, the limbs...
Bone Formation by Endochondral Ossification
Fractures: Bone Repair
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...
Bone Remodeling
Degenerative Disc Disease ll: Pathophysiology
