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HLA-Dr expression by tumor cells compared with survival in high grade astrocytomas
M L Rossi1, N R Jones, G F Karr
1Dept. of Neuropathology and Neurosurgery, Radcliffe Infirmary, Oxford, United Kingdom.
Tumori
|April 30, 1991
Abstract:
Frozen samples from 78 high grade astrocytomas were reacted with a monoclonal antibody directed against HLA-Dr invariant chain. Survival data was obtained for all 78 cases. HLA-Dr was expressed by a proportion of tumor cells in 65/78 (83%). Comparison of the survival of positive and negative cases showed that the difference was not statistically significant (p = 0.4). The relevance of the finding is discussed in the context of the immunoreaction to brain tumors.