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Back pain after photodynamic therapy with verteporfin
Alfredo Pece1, Maria Vadalà, Renato Manzi
1Department of Ophthalmology, Melegnano Hospital, Via Pandina 1, Vizzolo Predabissi, Melegnano, 20077 Milan, Italy. pece.retina@mclink.it
American Journal of Ophthalmology
|February 24, 2006
Summary
Photodynamic therapy (PDT) can cause back pain in 2.6% of patients. Prophylactic treatment and adjusting infusion rates may prevent this side effect, possibly related to thromboxanes.
Area of Science:
- Ophthalmology
- Pharmacology
Background:
- Photodynamic therapy (PDT) is a treatment modality used for various conditions.
- Back pain is a potential adverse event associated with PDT.
Purpose of the Study:
- To determine the incidence of back pain following photodynamic therapy (PDT) with verteporfin.
- To explore potential preventive strategies for PDT-induced back pain based on its pathogenesis.
Main Methods:
- Retrospective case series analysis of 548 patients undergoing PDT with verteporfin.
- Observation of pain incidence, severity, and patient demographics during and after treatment.
Main Results:
- 14 patients (2.6%) experienced pain during PDT infusion.
- Older patients (mean age 81) with age-related macular degeneration were more affected.
- Prophylactic treatment before PDT significantly reduced pain incidence in subsequent treatments.
Conclusions:
- Back pain during PDT may be linked to elevated thromboxanes from verteporfin's liposomal formulation.
- Preventive measures include hydration, NSAIDs, and reduced infusion rates.
- Further research into the mechanism and prevention of PDT-associated back pain is warranted.
