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Updated: Aug 10, 2026
07:46
Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation
Published on: April 3, 2017
[Sarcoidosis and obesity]
Goran Belojević1, Jasmina Marić-Zivković
1Medicinski fakultet Univerziteta u Beogradu, Institut za higijenu i medicinsku ekologiju.
Medicinski Pregled
|March 11, 2006
Summary
Neurosarcoidosis affecting the hypothalamus can cause polyphagia and obesity. Early diagnosis and treatment are crucial for managing this rare but serious condition, potentially utilizing [18F]Au-198 thioglucose imaging.
Area of Science:
- Endocrinology and Metabolism
- Neurology
- Oncology
Context:
- Sarcoidosis is a multisystem inflammatory disease that can affect the central nervous system, including the hypothalamus.
- Hypothalamic sarcoidosis is rare, estimated in 1% of sarcoidosis patients, and can lead to significant hormonal and metabolic disturbances.
- Neurosarcoidosis carries a substantial mortality rate, emphasizing the need for timely diagnosis and intervention.
Purpose:
- To highlight the potential link between hypothalamic sarcoidosis and the development of polyphagia and morbid obesity.
- To present case reports illustrating hypothalamic sarcoidosis presenting with hyperphagia and obesity.
- To discuss the diagnostic utility of gold-198 thioglucose ([198Au]-thioglucose) imaging for hypothalamic obesity in neurosarcoidosis.
Summary:
- Polyphagia and morbid obesity in sarcoidosis patients may indicate neurosarcoidosis affecting the hypothalamic satiety centers.
- Case reports detail young patients with hypothalamic sarcoidosis presenting with severe hyperphagia, obesity, and altered insulin regulation.
- Experimental studies support the role of hypothalamic nuclei in energy balance regulation, with disruption leading to obesity.
Impact:
- Early identification of hypothalamic sarcoidosis is critical due to its high lethality.
- The findings suggest [198Au]-thioglucose imaging as a potential diagnostic tool for hypothalamic obesity in neurosarcoidosis.
- This research contributes to understanding the complex interplay between sarcoidosis, the hypothalamus, and metabolic dysfunction.
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