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Updated: Aug 10, 2026

Assessment of Cocaine-induced Behavioral Sensitization and Conditioned Place Preference in Mice
Published on: February 18, 2016
[Acute intoxication due to cocaine. Review of one case]
M Solano Remírez1, J P Velilla Alcubilla, M T Alvarez Frías
1Servicio de Medicina Interna, Hospital de Navarra, Pamplona, Spain. manoloso@eresmas.com
Abstract:
Cocaine is a drug with distribution and consumption throughout the world. Its consumption extended mainly in the decades 1980-1990. The drugs produces cardiovascular effects following chronic administration and overdose, due to their potent vasoconstrictor effect secondary to the increase of synaptic concentrations of the monamine neurotransmitter dopamine, norepinephrine, and serotonin by binding to transporter proteins and blocking reuptake. Renal insufficiency due to rhabdomyolysis, and cardiovascular dysfunction have been reported following cocaine abuse, and may be fatal. We report a patient who developed renal insufficiency due to rhabdomyolysis and a cardiovascular disorder associated with cocaine abuse. We review the disorders induced by cocaine abuse and their treatment.
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