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Excipients for direct compaction--an update
Gerad K Bolhuis1, N Anthony Armstrong
1Department of Pharmaceutical Technology and Biopharmacy, University of Groningen, Groningen, The Netherlands. g.k.bolhuis@rug.nl
Pharmaceutical Development and Technology
|March 21, 2006
Summary
This review updates the 1996 assessment of excipients for direct tablet compaction. It covers new single-component and coprocessed filler-binders and advances in understanding their optimal design and function.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
Background:
- The direct compaction of tablets is a critical pharmaceutical manufacturing process.
- A foundational review of excipients for direct compaction was published in 1996 by Bolhuis and Chowhan.
- Significant advancements have occurred in the field since the initial review.
Purpose of the Study:
- To provide an updated review of excipients utilized in direct tablet compaction.
- To highlight new developments in single-component and coprocessed filler-binders.
- To discuss recent progress in understanding the mechanisms and optimal design of these excipients.
Main Methods:
- Literature review of scientific publications and industry reports.
- Analysis of new excipient introductions and their properties.
- Synthesis of current understanding regarding excipient functionality in direct compaction.
Main Results:
- Introduction of novel single-component and coprocessed filler-binders.
- Enhanced comprehension of the functional mechanisms of excipients during compaction.
- Development of strategies for optimizing excipient design for improved tablet properties.
Conclusions:
- The field of direct compaction excipients has seen substantial innovation.
- A deeper understanding of excipient science facilitates the development of superior materials.
- Optimized excipient design is key to efficient and effective tablet manufacturing.
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