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Excipients for direct compaction--an update.

Gerad K Bolhuis1, N Anthony Armstrong

  • 1Department of Pharmaceutical Technology and Biopharmacy, University of Groningen, Groningen, The Netherlands. g.k.bolhuis@rug.nl

Pharmaceutical Development and Technology
|March 21, 2006
PubMed
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This review updates the 1996 assessment of excipients for direct tablet compaction. It covers new single-component and coprocessed filler-binders and advances in understanding their optimal design and function.

Area of Science:

  • Pharmaceutical Sciences
  • Materials Science

Background:

  • The direct compaction of tablets is a critical pharmaceutical manufacturing process.
  • A foundational review of excipients for direct compaction was published in 1996 by Bolhuis and Chowhan.
  • Significant advancements have occurred in the field since the initial review.

Purpose of the Study:

  • To provide an updated review of excipients utilized in direct tablet compaction.
  • To highlight new developments in single-component and coprocessed filler-binders.
  • To discuss recent progress in understanding the mechanisms and optimal design of these excipients.

Main Methods:

  • Literature review of scientific publications and industry reports.
  • Analysis of new excipient introductions and their properties.

Related Experiment Videos

  • Synthesis of current understanding regarding excipient functionality in direct compaction.

    • Main Results:

    • Introduction of novel single-component and coprocessed filler-binders.
    • Enhanced comprehension of the functional mechanisms of excipients during compaction.
    • Development of strategies for optimizing excipient design for improved tablet properties.

    Conclusions:

    • The field of direct compaction excipients has seen substantial innovation.
    • A deeper understanding of excipient science facilitates the development of superior materials.
    • Optimized excipient design is key to efficient and effective tablet manufacturing.