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Cancer surgery: risks and opportunities.

J C Coffey1, M J F Smith, J H Wang

  • 1Department of Surgery, Cork University Hospital, University College Cork, National University of Ireland. calvincoffey@hotmail.com

Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology
|March 21, 2006
PubMed
Summary
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Tumor removal may unexpectedly accelerate cancer regrowth, a phenomenon termed perioperative tumor growth. This review highlights mechanisms and urgent needs for therapies to counteract this effect during the critical perioperative period.

Area of Science:

  • Oncology
  • Surgical Oncology
  • Cancer Biology

Background:

  • Emerging evidence suggests tumor removal can create a permissive environment for residual cancer growth.
  • This phenomenon, known as perioperative tumor growth, challenges traditional surgical approaches.
  • The perioperative period is currently underutilized for therapeutic interventions.

Purpose of the Study:

  • To review literature supporting the concept of perioperative tumor growth.
  • To outline current knowledge of the underlying biological mechanisms.
  • To identify potential therapeutic targets for intervention.

Main Methods:

  • Literature review of studies investigating tumor growth post-excision.
  • Analysis of proposed biological mechanisms driving accelerated tumor progression.

Related Experiment Videos

  • Identification of therapeutic strategies based on mechanistic insights.

    • Main Results:

    • Multiple studies indicate that surgical removal of tumors can stimulate the growth of remaining cancer cells.
    • Key mechanisms involve host-derived factors and inflammatory responses potentiating tumor proliferation.
    • The perioperative window presents a critical opportunity for intervention.

    Conclusions:

    • Tumor removal may inadvertently promote residual disease growth.
    • Understanding perioperative mechanisms is crucial for developing novel therapeutic strategies.
    • Clinical trials are urgently needed to test agents that mitigate adverse host-tumor interactions during the perioperative period.