[Disorders of liver oxidative metabolism during experimental obesity]

Evidence of cause-and-effect relation between obesity and severe metabolic disorders, including damages of lipid exchanges and liver metabolism, indicate to the significance of this problem for current medicine. Obesity alters adipose tissue metabolic and endocrine function and leads to an increased release of free fatty acids, that contribute to the obesity associated complications. The aim of our study was the investigate liver oxidative metabolism disorders during obesity and appreciation of possibility of correction of this disorders by green tea katechins. During experiments decreasing of intensity of electron transport chain in liver mitochondria has been revealed. That increases possibility of uncoupled electrons leakage and formation of superoxyde radicals. Chronic production of reactive oxygen species during obesity promotes the intensification of free radical processes, developing of oxidative stress and appears by lipoperoxil radical's formation in liver. That indicates to the changes of membrane' selectively permeability and homeostasis disorders in liver. Under the influence of green tea catechizes the mitochondrial and microsome electron transport chain disorders restores and intensity of peroxidation decreases.