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Updated: Aug 9, 2026

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
New pathway for the metabolism of pentitols
1Laboratory of Microbiology and Immunology, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20014.
Abstract:
Certain strains of Lactobacillus casei can grow at the expense of one or more pentitols. These microorganisms possess a pentitol phosphate pathway that appears to be analogous to the hexitol phosphate pathway found in many facultatively anaerobic bacteria. Pentitol is transported into the cell by a phospho enolpyruvate phosphotransferase system that converts it to pentitol phosphate, whereupon a specific dehydrogenase oxidizes the intermediate product to ketopentose phosphate. The ketopentose phosphate is subsequently converted to xylulose-5-P and enters one of the pathways of central metabolism.
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