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[Radiotherapy of prostatic carcinoma].
H Fuse1, T Katayama, S Akimoto
1Department of Urology, Faculty of Medicine, Toyama Medical and Pharmaceutical University.
Hinyokika Kiyo. Acta Urologica Japonica
|August 1, 1991
Summary
External radiotherapy is effective for localized prostate cancer, with survival rates varying by stage. Endocrine therapy can help manage recurrences after radiation, and most complications were minor.
Area of Science:
- Oncology
- Radiation Oncology
- Urologic Oncology
Context:
- Prostate cancer is a significant health concern, necessitating effective treatment modalities.
- External radiotherapy is a primary treatment for localized prostate adenocarcinoma.
- Treatment outcomes and recurrence patterns require thorough investigation.
Purpose:
- To evaluate the efficacy and outcomes of external radiotherapy for localized prostate adenocarcinoma.
- To analyze recurrence patterns and the role of endocrine therapy in treatment failure.
- To assess survival rates and complications associated with radiotherapy.
Summary:
- Forty-one patients with localized prostate adenocarcinoma received curative external radiotherapy (fast neutron and/or Liniac X-ray).
- Twenty-six cases achieved good local control; 15 recurred and received endocrine therapy.
- Five-year disease-free survival rates were 86% (Stage A2), 66% (Stage B), and 47% (Stage C). Overall survival rates were 100%, 100%, and 53%, respectively.
- Well-differentiated tumors showed better prognosis. Endocrine therapy was effective in 58% of recurrent cases. Complications were generally mild.
Impact:
- External radiotherapy demonstrates a favorable safety profile and efficacy for localized prostate cancer.
- Findings support the use of radiotherapy as a primary treatment option.
- Endocrine therapy serves as a valuable adjunct for managing radiotherapy failures.