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Related Concept Videos

NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Treatment Resistent Cancers02:56

Treatment Resistent Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists01:28

Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists

Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy.  SP binds and activates these...

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Related Experiment Video

Updated: Jul 26, 2026

Assessing Specificity of Anticancer Drugs In Vitro
09:39

Assessing Specificity of Anticancer Drugs In Vitro

Published on: March 23, 2016

Targeting NF-kappaB in anticancer adjunctive chemotherapy.

Burkhard Haefner1

  • 1Department of Oncology, Johnson & Johnson Pharmaceutical Research and Development, Beerse, Belgium.

Cancer Treatment and Research
|April 14, 2006
PubMed
Summary

Despite decades of research, cancer remains a significant challenge. Targeted combination therapy, particularly using NF-kappaB inhibitors, shows promise for more effective cancer treatment.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • The 'war on cancer' has seen limited success over three decades, with monotherapy often only delaying disease progression.
  • Initial hopes for cures from molecular biology and high-throughput screening have not fully materialized.
  • The 'one-gene-one target-one drug' approach has proven insufficient for most cancers.

Purpose of the Study:

  • To evaluate the limitations of current cancer treatment strategies.
  • To propose a shift from monotherapy to combination therapy for improved outcomes.
  • To identify promising therapeutic agents for future cancer treatment regimens.

Main Methods:

  • Review of existing cancer research and treatment outcomes.
  • Analysis of the efficacy of targeted monotherapy.

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An Orthotopic Sciatic Nerve Xenograft for Neurofibromatosis Type 1 Neurofibromas

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Last Updated: Jul 26, 2026

Assessing Specificity of Anticancer Drugs In Vitro
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Isolation of Primary Cancer-Associated Fibroblasts from a Syngeneic Murine Model of Breast Cancer for the Study of Targeted Nanoparticles
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  • Evaluation of the potential of combination therapy strategies.

    • Main Results:

    • Single-drug treatments for cancer are generally ineffective for achieving cures.
    • Combination therapy is emerging as a necessary strategy for more effective cancer treatment.
    • NF-kappaB inhibitors show potential as key components in anticancer combination therapies.

    Conclusions:

    • Rationally targeted monotherapy is inadequate for curing most cancers.
    • Rationally targeted combination therapy represents the future of cancer treatment.
    • Inhibitors of NF-kappaB are poised to become crucial in combination cancer therapy.