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Timed-release depot for anticancer agents.

S Yolles, T D Leafe, F J Meyer

    Journal of Pharmaceutical Sciences
    |January 1, 1975
    PubMed
    Summary
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    Researchers studied timed-release anticancer drugs from poly (lactic acid) composites in rats. Cyclophosphamide showed higher release (67%) than cis-dichlorodiammineplatinum (II) (9.3%) due to solubility differences.

    Area of Science:

    • Biomaterials Science
    • Polymer Chemistry
    • Pharmacology

    Background:

    • Controlled drug delivery systems are crucial for effective cancer therapy.
    • Poly (lactic acid) is a biodegradable polymer with potential for drug encapsulation.
    • Understanding drug release kinetics is vital for optimizing therapeutic outcomes.

    Purpose of the Study:

    • To investigate the timed-release of two anticancer agents, cyclophosphamide and cis-dichlorodiammineplatinum (II), from poly (lactic acid) composites.
    • To compare the release profiles of these drugs and explore factors influencing their diffusion.
    • To evaluate the utility of electron spectroscopy chemical analysis in studying drug diffusion in polymer matrices.

    Main Methods:

    • Preparation of poly (lactic acid) composites loaded with cyclophosphamide and cis-dichlorodiammineplatinum (II).

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  • In vivo drug release studies in a rat model over 34 days.
  • Analysis of drug diffusion using electron spectroscopy chemical analysis.

    • Main Results:

    • Cyclophosphamide-poly (lactic acid) composites exhibited a significant release of 67% within 34 days.
    • Cis-dichlorodiammineplatinum (II)-poly (lactic acid) composites showed a substantially lower release of 9.3% over the same period.
    • Differences in drug release were attributed to varying drug solubilities within the polymer matrix.

    Conclusions:

    • Poly (lactic acid) composites demonstrate differential release kinetics for anticancer agents.
    • Drug solubility in the polymer significantly impacts the release rate of encapsulated agents.
    • Electron spectroscopy chemical analysis is a valuable tool for characterizing drug diffusion in biomaterials.