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[Specific skin infiltration in Hodgkin's disease]
M Winzer1, W Müller, H Arnholdt
1Klinik für Dermatologie und Venerologie, Medizinischen Universität Lübeck.
Summary
A skin biopsy revealed a painless tumor with cells resembling Hodgkin
Area of Science:
- Dermatology and Oncology
- Pathology
Background:
- Cutaneous involvement in Hodgkin's disease is rare.
- Early diagnosis is crucial for effective treatment.
Observation:
- A 60-year-old man presented with a centrally ulcerated, painless axillary skin tumor.
- Enlarged, firm axillary lymph nodes were noted.
- Skin biopsy showed a mixed inflammatory infiltrate with neoplastic cells resembling Hodgkin- and Reed-Sternberg cells.
Findings:
- Immunohistochemistry confirmed CD-30 (Ki-1) antigen expression on atypical giant cells.
- Excision and histology of lymph nodes confirmed classical Hodgkin's disease, mixed cellularity type.
- This indicated primary cutaneous Hodgkin's disease.
Implications:
- Highlights the importance of considering Hodgkin's disease in the differential diagnosis of unusual skin tumors.
- Emphasizes the role of immunohistochemistry in diagnosing rare cutaneous lymphomas.
- Suggests that primary cutaneous Hodgkin's disease can present as a solitary skin lesion.