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Effect of icodextrin-based peritoneal dialysis solution on peritoneal membrane.
Misaki Moriishi1, Hideki Kawanishi, Hiroshi Watanabe
1Department of Artificial Organs, Akane-Foundation Tsuchiya Hospital, Hiroshima, Japan. usagi@tsuchiya-hp.jp
Summary
Icodextrin-based peritoneal dialysis solution increased peritoneal cell counts and fibrinogen degradation product (FDP) levels, suggesting a subclinical inflammatory response. Further research is needed to clarify long-term effects on the peritoneum.
Area of Science:
- Nephrology
- Peritoneal Dialysis
- Biomaterials
Background:
- The peritoneal membrane is crucial for dialysis efficacy.
- Assessing the biocompatibility of dialysis solutions is essential for patient outcomes.
- Icodextrin is used in peritoneal dialysis, but its long-term effects require evaluation.
Purpose of the Study:
- To evaluate the effects of icodextrin-based peritoneal dialysis solution on the peritoneal membrane.
- To compare peritoneal membrane markers before and after switching from a glucose-based solution to icodextrin.
Main Methods:
- Studied 8 anuric patients undergoing continuous ambulatory peritoneal dialysis.
- Measured effluent cell counts, cancer antigen 125 (CA125), fibrinogen degradation product (FDP), and interleukin-6 (IL-6) levels.
- Compared these markers before and at 12 and 36 weeks after switching to icodextrin.
Main Results:
- Mean effluent cell counts significantly increased after 12 and 36 weeks of icodextrin use (p < 0.01).
- Effluent FDP levels were significantly higher with icodextrin compared to glucose solution (p < 0.01).
- Effluent CA125 and IL-6 levels showed no significant changes.
Conclusions:
- Icodextrin-based solution induced a subclinical inflammatory response in the peritoneum.
- The biocompatibility of icodextrin is not consistently superior to glucose solutions.
- Long-term effects of icodextrin on the peritoneum warrant further investigation.