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Prompt hydrolysis of adenosine 3', 5'-cyclic monophosphate by Co(III) complexes
K Yonezawa1, Y Matsumoto, M Komiyama
1Institute of Materials Science, University of Tsukuba, Ibaraki, Japan.
Nucleic Acids Symposium Series
|January 1, 1991
Abstract:
Adenosine 3',5'-cyclic phosphate (cAMP) is efficiently hydrolyzed at pH 7, 50 degrees C by use of [Co-(trien) (H2O)2]3+ and [Co(tme)2-(H2O)2]3+ complexes as catalysts: trien (diethylenetriamine) and tme (1,1,2,2-tetramethylethylenediamine). The acceleration is remarkable (10(8) to 10(9) fold), decreasing half-life of cAMP from 660,000 years to 7-15 hours.