Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Genetic polymorphisms and infections].

N Joram1, E Lopez, J Texereau

  • 1Service de réanimation médicale, hôpital Cochin-Port-Royal, 27 rue du Faubourg-Saint-Jacques, 75014 Paris, France.

Medecine Et Maladies Infectieuses
|May 16, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Portable Home-Use Triglyceride Meter Demonstrates Good Agreement With Plasma Laboratory Measures During Pregnancies Complicated by Metabolic Disease.

Endocrinology, diabetes & metabolism·2026
Same author

Influence of secretome from porcine cardiosphere-derived cells on porcine macrophage polarization and their possible implications for cardiac remodeling post-myocardial infarction <i>in vitro</i>.

Frontiers in cell and developmental biology·2025
Same author

Diffuse alveolar hemorrhage as a clinical manifestation of cardiac angiosarcoma in a pregnant woman with antiphospholipid syndrome: case report and review of the literature.

Ecancermedicalscience·2025
Same author

Treatment outcomes in sinonasal aspergillosis in dogs in the United Kingdom: 436 cases (2011-2021).

The Journal of small animal practice·2025
Same author

Can we reduce the risk of neurological injury in critically ill children on initiation of ECLS? A narrative review of potential modifiable factors.

Perfusion·2025
Same author

Impact of heteroresistance on treatment outcomes of people with drug-resistant TB.

IJTLD open·2024
Same journal

[Etiology and clinical expression of angina].

Medecine et maladies infectieuses·2024
Same journal

[Rational use of antibiotics treatment in acute bronchitis].

Medecine et maladies infectieuses·2024
Same journal

Medecine et maladies infectieuses·2024
Same journal

[Detection of human rotaviruses in faeces : comparison of five methods].

Medecine et maladies infectieuses·2024
Same journal

Medecine et maladies infectieuses·2024
Same journal

Medecine et maladies infectieuses·2024
See all related articles

Genetic variations in immune response genes influence infection susceptibility. Specific mutations in Toll-like receptors (TLRs) like TLR2, TLR4, and TLR5 can increase or decrease the risk of severe infections such as sepsis and legionellosis.

Area of Science:

  • Immunogenetics
  • Infectious Disease Epidemiology
  • Human Genetics

Background:

  • Human response to infectious agents varies due to genetic differences.
  • Genes involved in pathogen recognition, inflammation, and coagulation influence infection risk.
  • Twin studies show higher infection risk in identical twins, suggesting a genetic component.

Purpose of the Study:

  • To explore the role of genetic variants in human susceptibility to infectious diseases.
  • To investigate specific gene polymorphisms in Toll-like receptors (TLRs) and their association with severe infections.
  • To understand how genetic abnormalities contribute to sepsis and other infectious conditions.

Main Methods:

  • Review of recent studies on genetic variants and infectious disease risk.

Related Experiment Videos

  • Analysis of specific gene mutations and polymorphisms in TLR2, TLR4, and TLR5.
  • Examination of associations between genetic variations and conditions like septic shock, legionellosis, meningococcemia, and RSV bronchiolitis.

    • Main Results:

    • A mutation in TLR2 can block responses to Gram-positive bacteria, increasing septic shock risk.
    • TLR4 polymorphisms are linked to septic shock from Gram-negative bacilli but may protect against legionellosis.
    • TLR4 variants are risk factors for severe infections in children, including meningococcemia and RSV bronchiolitis.
    • A nonfunctional TLR5 receptor due to a stop codon polymorphism is associated with severe legionellosis.

    Conclusions:

    • Genetic polymorphisms in immune response genes, particularly TLRs, significantly impact susceptibility to various infectious diseases.
    • Understanding these genetic factors is crucial for identifying individuals at higher risk for severe infections.
    • Further research into these genetic polymorphisms will pave the way for targeted therapies for sepsis and other infectious conditions.