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Related Concept Videos

Lipid-Lowering Drugs: Statins and Miscellaneous Agents01:20

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
Lipids: Dietary Sources and Requirements01:18

Lipids: Dietary Sources and Requirements

Lipids are an essential component of a balanced human diet. Triglycerides, which make up the majority of dietary lipids, are found in both saturated fats—commonly present in meat, dairy products, and certain tropical plants like coconut, and hydrogenated oils such as margarine and baking shortenings (trans fats)—and unsaturated fats, which are abundant in seeds, nuts, olive oil, and most vegetable oils. The main sources of cholesterol include egg yolks, various meats and organ meats, shellfish,...
Overview of Lipid Metabolism01:24

Overview of Lipid Metabolism

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Lipolysis: The Breakdown of Lipids:
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Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

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Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight, compared...
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

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In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses a challenge in...
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Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
07:29

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Published on: October 12, 2017

Hyperlipidemia in children.

Brian W McCrindle1

  • 1Division of Cardiology, Department of Pediatrics, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada M5G 1X8. brian.mccrindle@sickkids.ca

Thrombosis Research
|May 20, 2006
PubMed
Summary
This summary is machine-generated.

Childhood hyperlipidemia, linked to obesity, impacts vascular health and initiates atherosclerosis. Early screening and interventions, including statins for high-risk cases, are crucial despite long-term safety questions.

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Area of Science:

  • Pediatrics
  • Cardiovascular Health
  • Metabolic Disorders

Background:

  • Childhood hyperlipidemia is a growing concern, paralleling the global obesity epidemic.
  • It can impair vascular endothelial function and initiate atherosclerosis in children.
  • Severe lipid abnormalities often stem from primary familial dyslipidemias.

Purpose of the Study:

  • To review the prevalence and implications of hyperlipidemia in children.
  • To discuss current screening and intervention strategies.
  • To evaluate the role of lipid-lowering therapies in pediatric populations.

Main Methods:

  • Review of existing literature on childhood hyperlipidemia.
  • Analysis of pathological and non-invasive studies linking vascular changes to pediatric dyslipidemia.
  • Assessment of current screening guidelines and therapeutic options.

Main Results:

  • Strong associations exist between vascular changes and hyperlipidemia in children.
  • Family history and parental hyperlipidemia are key screening indicators.
  • Dietary interventions show modest lipid-lowering effects.
  • Statins are increasingly used in high-risk children with comparable efficacy and safety to adults, though long-term data is pending.

Conclusions:

  • Hyperlipidemia in children is a significant cardiovascular risk factor requiring proactive management.
  • Targeted screening and intervention are essential for high-risk individuals.
  • While statin therapy shows promise, ongoing monitoring for long-term effects in children is necessary.