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[Secretion and expression of E-selectin in nasal polyps]
Houyong Kang1, Jianhua Zhang, Shixiong Tang
1Department of Otorhinolaryngolgy, Ningbo First Hospital, Zhejiang Province, Ningbo, 315010, China. kanghouyong@sohu.com
Lin Chuang Er Bi Yan Hou Ke Za Zhi = Journal of Clinical Otorhinolaryngology
|May 26, 2006
Summary
E-selectin levels are significantly elevated in nasal polyps, indicating its crucial role in chronic inflammation and polyp development. This finding highlights E-selectin as a potential therapeutic target for nasal polyps.
Area of Science:
- Immunology
- Otorhinolaryngology
- Cell Biology
Background:
- Nasal polyps are associated with chronic inflammation.
- The role of specific adhesion molecules in nasal polyp pathogenesis is not fully understood.
Purpose of the Study:
- To investigate the significance of E-selectin in nasal polyps.
- To quantify E-selectin levels and expression in nasal polyp tissue compared to normal turbinates.
Main Methods:
- Enzyme-linked immunosorbent assay (ELISA) was used to measure E-selectin levels.
- Immunohistochemistry and HE staining were employed to study E-selectin expression and cellular infiltration.
- Samples were obtained from 25 nasal polyp patients and 9 controls.
Main Results:
- Nasal polyps showed significantly higher E-selectin levels (42.58 ± 13.52 μg/L) compared to controls (11.35 ± 3.17 μg/L) (P < 0.001).
- E-selectin expression was prominent in vascular endothelium, gland cells, and the extracellular matrix of nasal polyps.
- Expression in polyp vascular endothelium (84.0%) and matrix (92.0%) was significantly higher than in turbinates (P = 0.05, 0.01).
- A positive correlation was found between E-selectin expression in vascular endothelium and the matrix (r = 0.544, P < 0.01).
Conclusions:
- Nasal polyp tissue exhibits significantly increased secretion and expression of E-selectin.
- E-selectin likely plays a key role in the chronic inflammatory processes underlying nasal polyp formation.
- E-selectin mediates inflammation cell attachment, migration, and activation in nasal polyps.