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Assisted reproductive technology surveillance--United States, 2003
Victoria Clay Wright1, Jeani Chang, Gary Jeng
1Division of Reproductive Health, National Center for Chronic Disease Prevention and Health Promotion, Atlanta, GA 30341, USA. vwright@cdc.gov
Morbidity and Mortality Weekly Report. Surveillance Summaries (Washington, D.C. : 2002)
|May 26, 2006
Summary
Assisted reproductive technology (ART) procedures in 2003 led to many multiple births, increasing risks for mothers and infants. Limiting embryo transfers and considering infant outcomes are crucial for ART safety and efficacy.
Area of Science:
- Reproductive Medicine
- Public Health
- Biostatistics
Background:
- Assisted reproductive technology (ART) procedures, including in vitro fertilization, are associated with higher rates of multiple births compared to natural conception.
- Multiple births increase risks for maternal complications, premature delivery, low birthweight infants, and potential long-term infant disabilities.
Purpose of the Study:
- To analyze national data on ART procedures performed in the United States in 2003.
- To assess the outcomes of ART procedures, including live-birth rates and the incidence of multiple births.
- To identify factors influencing ART success and the risk of multiple gestations.
Main Methods:
- Data collection mandated by the Fertility Clinic Success Rate and Certification Act (FCSRCA).
- Collaboration between the CDC and the Society for Assisted Reproductive Technology (SART) for data acquisition from ART medical centers.
- Compilation and analysis of ART procedure data from 1997 onwards, with a focus on 2003.
Main Results:
- In 2003, 122,872 ART procedures resulted in 35,785 live births and 48,756 infants.
- Freshly fertilized donor eggs yielded the highest live-birth rates (51%).
- Nationwide, 51% of ART-conceived infants were part of multiple births, with risks varying by embryo type, transfer number, and maternal age. ART infants accounted for 18% of all multiple births.
Conclusions:
- ART success rates and live-birth outcomes are influenced by patient and treatment variables.
- ART significantly increases the risk of multiple births, necessitating careful consideration of patient age, procedure type, and embryo transfer numbers.
- Reducing embryo transfers and monitoring adverse infant outcomes like low birthweight and preterm delivery are essential for improving ART safety and efficacy.
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