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Related Experiment Videos

Increased PMN CD11b/CD18 expression following post-traumatic ARDS.

H H Simms1, R D'Amico

  • 1Division of Surgical Research, Rhode Island Hospital, Brown University School of Medicine, Providence 02903.

The Journal of Surgical Research
|April 1, 1991
PubMed
Summary
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Polymorphonuclear leukocytes (PMN) show increased cell surface expression and oxidative metabolism during adult respiratory distress syndrome (ARDS) development. These changes in circulating PMN may serve as early markers for ARDS in trauma patients.

Area of Science:

  • Immunology
  • Critical Care Medicine
  • Pathophysiology

Background:

  • Post-traumatic adult respiratory distress syndrome (ARDS) is a severe complication.
  • The role of polymorphonuclear leukocytes (PMN) in ARDS pathogenesis requires further elucidation.

Purpose of the Study:

  • To investigate the function of circulating pulmonary artery PMN in trauma patients.
  • To identify potential early markers for ARDS development in trauma patients.

Main Methods:

  • Assayed PMN functions including CD11b/CD18 expression, MTT-Formazan production, H2O2 production, and superoxide anion release.
  • Compared PMN function between trauma patients who developed ARDS and those who did not.
  • Performed longitudinal assays on patients at risk for ARDS.

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Main Results:

  • PMN from ARDS patients exhibited upregulated CD11b/CD18 expression and oxidative metabolism (MTT-Formazan, H2O2, superoxide anion release).
  • Significant increases in CD11b/CD18 expression and MTT-Formazan production were observed in patients prior to clinical ARDS recognition.
  • These functional changes in PMN occurred within 24 hours of ARDS diagnosis.

Conclusions:

  • Increased CD11b/CD18 expression on PMN cell surfaces coincides with ARDS.
  • PMN oxidative metabolism increases at the onset of ARDS.
  • Changes in circulating pulmonary artery PMN may serve as predictive markers for ARDS development in trauma patients.