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Encapsulation efficiency and controlled release characteristics of crosslinked polyacrylamide particles.
Malladi Sairam1, V Ramesh Babu, Boya Vijaya
1Drug Delivery Division, Center of Excellence in Polymer Science, Karnatak University, Dharwad 580 003, India.
International Journal of Pharmaceutics
|June 13, 2006
Summary
This study developed crosslinked polyacrylamide (pAAm) microparticles for controlled anticancer drug delivery. The particles successfully encapsulated and released 5-fluorouracil over 12 hours, showing potential for targeted cancer therapy.
Area of Science:
- Polymer Science
- Materials Science
- Drug Delivery Systems
Background:
- Polyacrylamide (pAAm) particles are versatile for drug encapsulation.
- Developing controlled-release systems for anticancer drugs like 5-fluorouracil is crucial for effective therapy.
Purpose of the Study:
- To synthesize and characterize crosslinked pAAm microparticles for in situ loading of 5-fluorouracil.
- To investigate the in vitro release kinetics of 5-fluorouracil from these microparticles.
Main Methods:
- Dispersion polymerization in a water-methanol medium using poly(vinyl pyrrolidone) (PVP) as a stabilizer.
- Characterization using differential scanning calorimetry (DSC), X-ray diffraction (XRD), and scanning electron microscopy (SEM).
- In vitro drug release studies in a pH 7.4 buffer solution.
Main Results:
- Spherical and oval-shaped pAAm microparticles were successfully prepared.
- DSC and XRD confirmed molecular-level dispersion of 5-fluorouracil within the pAAm matrix.
- Encapsulation efficiency and release profiles were influenced by crosslinking agent type/amount and drug loading.
Conclusions:
- Crosslinked pAAm microparticles provide a viable platform for the controlled, in situ loading and sustained release of 5-fluorouracil.
- The release of 5-fluorouracil was effectively controlled for up to 12 hours.
- This system demonstrates potential for improved anticancer drug delivery strategies.