Synthesis of conformationally constrained lysine analogues
Rakesh Ganorkar1, Amarnath Natarajan, Ahmed Mamai
1Department of Chemistry, University of Vermont, Burlington, Vermont 05405, USA.
The Journal of Organic Chemistry
|June 17, 2006
Abstract:
The synthesis of two conformationally constrained lysine analogues is reported. The synthesis of the novel analogue 1 based on the 3-aza-bicyclo[3.1.0]hexane system is accomplished from the known tricycle 3 in eight steps. The synthesis of the analogue 2 is accomplished in eight steps from 4-hydroxy proline. Both analogues are synthesized appropriately protected for Fmoc/Boc solid-phase peptide synthesis.
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