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Updated: Aug 7, 2026

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
Published on: June 13, 2021
Mental distress in mothers of child psychiatric patients
Ehsan Ullah Syed1, Saman Iqbal Zuberi
1Department of Psychiatry, The Aga Khan University, Karachi, Pakistan. ehsan.syed@aku.edu
Objective:
To determine whether caring for a child with mental health issues could lead to mental distress among mothers.
Design:
Cross-sectional study.
Place And Duration:
Outpatient Clinics of The Aga Khan University Hospital and PNS Shifa Hospital, Karachi, from January to June 2005.
Patients And Methods:
A total of 238 consecutive mothers bringing their children to child psychiatric and pediatric clinics were recruited over a 6-month period. As per inclusion criteria, 106 mothers of child psychiatric patients were compared to 132 mothers taken from pediatric clinics. They were asked to fill out a psychiatric screening instrument (WHO SRQ-20). Mothers' mental distress (score>or=10 on SRQ-20) and other potential risk or protective factors were measured.
Results:
Mental distress among mothers determined by WHO SRQ-20 was associated with their child attending a psychiatric clinic (odds ratio 2.51, 95% confidence interval 1.38-4.51). This association remained significant for age of mother being less than 30 years. No significant association was found with the number of children and duration of marriage.
Conclusion:
Mental distress among mothers is associated with the child having psychiatric problems. These mothers may represent a group who are at higher risk of depression. Early recognition and treatment of mental health problems in mothers may help reduce psychiatric morbidity in children.
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