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Seroprevalence of Helicobacter pylori in children with constitutional height retardation

Ayşin Taşar1, Erkan Kibrisli, Yildiz Dallar

  • 1Department of Pediatric, Ankara State Hospital, Ankara, Turkey. aysintasar@yahoo.com

The Turkish Journal of Gastroenterology : the Official Journal of Turkish Society of Gastroenterology
|July 11, 2006
PubMed

Insights

Helicobacter pylori infection is linked to constitutional height retardation in children. This study found significantly higher H. pylori antibody levels in growth-retarded children compared to controls, suggesting it

Area of Science:

  • Pediatric Endocrinology
  • Infectious Diseases
  • Human Growth and Development

Background:

  • Constitutional height retardation (CHR) is a condition affecting children's growth.
  • Environmental factors are hypothesized to influence CHR.
  • Helicobacter pylori (H. pylori) is a common bacterial infection.

Purpose of the Study:

  • To investigate the association between H. pylori infection and CHR in children.
  • To determine if H. pylori seroprevalence differs between children with CHR and those with normal growth.

Main Methods:

  • A case-control study involving 41 children with CHR and 40 controls.
  • Assessment of gastrointestinal symptoms in children and families.
  • Measurement of H. pylori antibody levels (IgG and CagA IgG) in both groups.

Main Results:

  • H. pylori IgG positivity was 78% in the CHR group versus 10% in controls.
  • H. pylori CagA IgG positivity was 85.4% in the CHR group versus 15% in controls.
  • Significantly higher seroprevalence of H. pylori antibodies in the CHR group (p<0.001).

Conclusions:

  • H. pylori infection is significantly more prevalent in children with constitutional height retardation.
  • These findings support H. pylori as a potential environmental factor contributing to growth retardation.
  • Further research is warranted to elucidate the mechanisms linking H. pylori to impaired growth.
Abstract

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