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Interaction of rifabutin with model membranes

Yu N Shakina1, V V Vostrikov, G M Sorokoumova

  • 1M. V. Lomonosov Moscow State Academy of Fine Chemical Technology.

Bulletin of Experimental Biology and Medicine
|July 20, 2006
PubMed
Summary

This study shows that rifabutin (a tuberculosis drug) binds to liposomes through electrostatic and hydrophobic interactions, influenced by phospholipid composition and ionic strength. This binding affects the drug's activity.

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