[ICAM-1 and immunological cell adhesion in the skin]

The adhesion molecule ICAM-1 mediates cell contact among leukocytes and between leukocytes and various non-lymphoid cells. A substantial body of experimental evidence indicates a crucial role of ICAM-1 in the biology of cutaneous inflammation. The current status of knowledge on ICAM-1 is reviewed and discussed with regard to the pathophysiology of inflammatory and neoplastic disorders of the skin.