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Surface modifications of bioglass immersed in TRIS-buffered solution. A multitechnical spectroscopic study
Marta Cerruti1, Claudia L Bianchi, Francesca Bonino
1Department of Chemistry I.F.M. and Center of Excellence NIS, University of Turin, Consortium INSTM, Research Unit of Turin University, Via P. Giuria 7, 10125 Torino, Italy. martacerruti@yahoo.com
The Journal of Physical Chemistry. B
|July 21, 2006
Summary
Bioglass 45S5 forms a bone-like hydroxy carbonate apatite layer in body fluid. This study confirms the proposed mechanism involving ion exchange and surface layer formation, advancing bone regenerative material science.
Area of Science:
- Biomaterials Science
- Materials Chemistry
- Surface Chemistry
Background:
- Bioglass 45S5 is a key material for bone regeneration.
- Its bioactivity involves forming a hydroxy carbonate apatite (HCA) layer in physiological conditions.
- The exact surface reaction mechanism is still under investigation.
Purpose of the Study:
- To analyze the surface modifications of Bioglass 45S5 particles during dissolution.
- To confirm the hypothesized mechanism of Bioglass reactivity.
- To gain deeper insights into the surface chemistry of Bioglass 45S5.
Main Methods:
- Dissolution of 2-mum-size Bioglass 45S5 particles in TRIS-buffered solution.
- Surface analysis using Transmission FT-IR, Raman Spectroscopy, and X-ray Photoelectron Spectroscopy (XPS).
- Comparison of spectral data with reference samples for precise band assignment.
Main Results:
- Confirmed the hypothesized mechanism of Bioglass 45S5 reactivity.
- Observed a decrease in surface H-bonding and water coordination during reaction.
- Identified a substitution of Na-bound carbonates by Ca-bound carbonates.
- The final calcium phosphate layer closely resembles carbonated hydroxyapatite.
Conclusions:
- The study validates the ion exchange and surface layer formation mechanism for Bioglass 45S5 bioactivity.
- Surface chemistry changes, including carbonate binding, are crucial for HCA layer formation.
- The resulting layer is a carbonated apatite, similar but not identical to bone mineral.
