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Published on: February 9, 2021
[Renal lithiasis. Biochemical changes in the follow-up]
Francisco R Spivacow1, Elisa E del Valle, José R Zancheta
1Instituto de Investigaciones Metabólicas, Libertad 836, 1012 Buenos Aires, Argentina. spiva@idim.com.ar
Medicina
|July 29, 2006
Summary
Biochemical changes frequently occur during renal lithiasis follow-up, particularly hypocitraturia. Patients with metabolic changes show higher recurrence rates, even without specific treatments.
Area of Science:
- Nephrology
- Biochemistry
- Urology
Background:
- Renal lithiasis (kidney stones) management requires monitoring for biochemical changes.
- Long-term follow-up is crucial for understanding disease progression and recurrence.
Purpose of the Study:
- To assess biochemical changes during the follow-up of patients with renal lithiasis.
- To identify the frequency and types of metabolic alterations in kidney stone patients.
Main Methods:
- Prospective study of 237 renal lithiasis patients over 27.3 months.
- Baseline and follow-up metabolic evaluations were performed.
- Exclusion of specific conditions like sponge kidney and urinary infections.
Main Results:
- Hypocitraturia was the most frequent additional diagnosis (43.1%), followed by hypercalciuria (20.8%) and uric acid abnormalities (16.5%).
- In patients followed >3 years, 33% recurred, with 23% showing changed metabolic diagnoses versus 11% with stable diagnoses (p < 0.002).
- Metabolic disorder changes were common and not solely linked to diet or medication.
Conclusions:
- Biochemical changes are frequently observed during renal lithiasis follow-up.
- Hypocitraturia is a common metabolic alteration in this patient group.
- Altered biochemical parameters correlate with higher recurrence rates, especially without treatment.
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