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Published on: December 13, 2024
Long-term release of fluocinolone acetonide using biodegradable fumarate-based polymers
A Haesslein1, H Ueda, M C Hacker
1Department of Bioengineering, Rice University, Houston, TX 77251-1892, USA.
Summary
Biodegradable poly(propylene fumarate) (PPF) matrices offer sustained intraocular drug delivery for eye diseases. These crosslinked PPF-based devices release fluocinolone acetonide (FA) for nearly 400 days, showing promise for long-term treatment.
Area of Science:
- Biomaterials Science
- Ophthalmology
- Drug Delivery
Background:
- Biodegradable polymers are crucial for sustained intraocular drug delivery systems targeting chronic posterior eye diseases.
- Poly(propylene fumarate) (PPF) exhibits hydrophobicity and tunable network density, making it a candidate for controlled drug release.
Purpose of the Study:
- To evaluate crosslinked PPF-based matrices as long-term delivery devices for fluocinolone acetonide (FA).
- To investigate the influence of drug loading and PPF:NVP ratio on FA release kinetics.
Main Methods:
- Fabrication of FA-loaded PPF rods via photo-crosslinking with N-vinyl pyrrolidone (NVP).
- Quantification of FA and NVP release using High-Performance Liquid Chromatography (HPLC).
- Assessment of matrix water content, degradation, and structural changes via gravimetry and micro-computed tomography.
Main Results:
- FA release was sustained in vitro for nearly 400 days across all formulations.
- Low initial burst release was observed, followed by diffusion and bulk erosion-controlled release (up to 1.7 microg/day).
- Drug loading and matrix composition significantly influenced burst effect and release kinetics.
Conclusions:
- Photo-crosslinked PPF-based matrices demonstrate potential as effective long-term intraocular drug delivery systems.
- The tunable properties of PPF matrices allow for controlled release of anti-inflammatory drugs like FA.
- These findings support the development of PPF for treating chronic posterior segment eye conditions.
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