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Updated: Aug 6, 2026
13:41
Use of Interferon-γ Enzyme-linked Immunospot Assay to Characterize Novel T-cell Epitopes of Human Papillomavirus
Published on: March 8, 2012
Genital human papillomavirus infection
Eileen F Dunne1, Lauri E Markowitz
1Division of STD Prevention, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA. Dde9@cdc.gov
Summary
Human papillomavirus (HPV) causes various cancers and warts. Research has improved understanding, leading to HPV testing for cervical cancer screening and an effective HPV vaccine for prevention.
Area of Science:
- Epidemiology
- Oncology
- Vaccinology
Background:
- Human papillomavirus (HPV) infection is a significant public health concern, linked to anogenital warts, cervical cancer, and other cancers.
- Epidemiology and natural history studies have advanced the understanding of HPV.
- Clinical trials have informed the use of HPV testing in cervical cancer screening and management.
Purpose of the Study:
- To provide clinicians with a review of genital HPV.
- To focus on the prevalence of HPV infection within the United States.
Main Methods:
- Review of epidemiological data.
- Analysis of natural history studies.
- Evaluation of clinical trial outcomes for HPV testing and vaccination.
Main Results:
- HPV infection is associated with anogenital warts and various cancers.
- HPV testing is recommended for cervical cancer screening and management.
- Prophylactic HPV vaccines demonstrate high efficacy against HPV types 6, 11, 16, and 18.
Conclusions:
- An HPV vaccine targeting specific HPV types was licensed in 2006 for females aged 9-26.
- Continued research and understanding of HPV are crucial for prevention strategies.
- This review focuses on the prevalence of genital HPV in the US for clinical application.
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