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Synthesis and Evaluation of a Ruthenium-based Mitochondrial Calcium Uptake Inhibitor
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[Study on synthesis and purification of calcium 5-formyltetrahydrofolate]
Biao Wang1, Zhi-li Zhang, Ying Guo
1Department of Chemical Biology, School of Pharmaceutical Science, State Key laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100083, China.
Objective:
To establish a new approach to synthesis and purification of calcium 5-formytetrahydrofolate.
Methods:
Target compound was synthesized by the use of folic acid as starting material via reduction, formylation, hydrolysis and salt formation
Results:
The structure of calcium 5-formytetrahydrofolate was confirmed by UV, 1H-NMR and elemental analysis and the overall yield was 54%-59%, 14%-17% higher than the reported yield.
Conclusion:
A convenient synthetic route was developed and it would be suitable for industrial production.
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