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Updated: Aug 6, 2026
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The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
Erythrokeratoderma variabilis successfully treated with topical tazarotene
Stephen Yoo1, Soheil Simzar, Karen Han
1Department of Dermatology, University of Texas Southwestern, Dallas, Texas, USA.
Pediatric Dermatology
|August 22, 2006
Summary
Erythrokeratoderma variabilis, a rare skin condition, presents unique challenges. A novel case demonstrates successful treatment with topical tazarotene, offering new hope for patients.
Area of Science:
- Dermatology
- Genodermatoses
- Ichthyoses
Background:
- Erythrokeratoderma variabilis (EGV), or Mendes da Costa syndrome, is a rare genodermatosis.
- Characterized by transient erythema and hyperkeratotic plaques.
- Existing treatments show limited efficacy.
Observation:
- A pediatric case of EGV with no family history was observed.
- The patient presented with classic EGV manifestations.
- Previous treatments had variable success.
Findings:
- Successful management of EGV in a pediatric patient using topical tazarotene.
- Topical tazarotene demonstrated significant improvement.
- This case highlights a potential new therapeutic option.
Implications:
- Topical tazarotene may be an effective treatment for Erythrokeratoderma variabilis.
- Further research is warranted to confirm efficacy and safety.
- Offers a promising alternative for managing this rare genodermatosis.
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