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Updated: Jul 20, 2026
An Ectopic Chemokine Expression Model for Testing Macrophage Recruitment In Vivo
Published on: September 25, 2019
[Setup a model for study the interfere between chemokine and immunocyte]
Mike Min1, Chaowu Ma, Yuqin Zhan
1Department of Otolaryngology, No. 117 Hospital of PLA, Hangzhou 310004, China. meek@263.net
Objective:
To investigated the effect of chemoattractant of rhTNF-alpha on TB-LCL. Set up a model for study the interaction between cytokine and B cells.
Method:
PTC were transfected with Epstein Barr virus, to get tonsil B lymphoblastic cell line(TB-LCL).
Result:
It was found rhTNF-alpha can chemotactic TB-LCL, in a dose-dependent manner and this chemotactic effect can be blocked by the neutralizing antibody E6 against TNF.
Conclusion:
This is an useful model in study the interfere between chemokine and immunocyte.
