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Updated: Jul 20, 2026

Rapid Generation of Amyloid from Native Proteins In vitro
05:48

Rapid Generation of Amyloid from Native Proteins In vitro

Published on: December 5, 2013

Amyloid formation may involve alpha- to beta sheet interconversion via peptide plane flipping.

James E Milner-White1, James D Watson, Guoying Qi

  • 1Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, United Kingdom. j.milner-white@bio.gla.ac.uk

Structure (London, England : 1993)
|September 12, 2006
PubMed
Summary

Toxic amyloid prefibrillar intermediates may form via alpha-sheet to beta-sheet conversion. This transition occurs through peptide plane flipping, a common mechanism observed in protein structures.

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